Simulations

Main content

PharmaCalc: Pharmacokinetic simulations

PharmaCalc requirs Java (http://www.java.com/en/).

Distribution of ionization species and logD-pH profiles

Distribution of ionization species Excel file

  • to calculate the mole fractions of ionization species of compounds with up to ten pKa values
  • to simulate partitioning of ionization species in octanol/buffer

IC50 determination with Excel Solver

Template for IC50 calculations Excel file

PET kinetic modeling: Matlab codes

Simulate mouse FDG input function and brain time activity curve

FDG kinetic simulations (M, 18 KB) Matlab script

Acknowledge: Stefanie D. Krämer, Radiopharmaceutical Sciences / Biopharmacy, ETH Zurich, Switzerland. Cite: M.F. Alf et al., EJNMMI Research 2013, 3:61

 
 
Page URL: http://www.biopharmacy.ethz.ch/simulations.html
24.04.2017
© 2017 Eidgenössische Technische Hochschule Zürich